Rapid Test for the detection of IgM antibodies to S.typi
Ideally, the Widal test should use the tube technique with paired serum being tested one week apart.Even using this technique, however specificity and sensitivity of ~ 40% have been reported*. Delay in turn around time using the standard tube technique has persuaded most users to perform the Widal test in the stat mode. The Widal stat test does not differentiate positivity associated with antibodies produced due to current ongoing infection and base level titers due to past exposure/infection with S.typhi.
Since IgM class of S.typhi specific antibodies are formed early and only in an ongoing infection, their detection can serve as a more sensitive marker for the early and accurate diagnosis of current S.typhi infection.
ENTEROCHECK -WB is a rapid immunochromatographic test for specific and qualitative detection of IgM class of antibodies directed to Lipopolysaccharide (LPS) 'O' of S.typhi in human serum /plasma/whole blood. he test has high practical applications in early detection of typhoid feer, confirming Widal results, in febrile related pediatric cases and as an adjunct to culture methods.